Building an efficient and low-carbon integrated energy system is an important way to achieve the carbon peak and carbon neutrality goals.Therefore，a regional integrated energy system （RIES） considering flexible and coordinated source-load response，and refined utilization of hydrogen energy is proposed.Firstly，a refined utilization model of hydrogen energy，including wind power hydrogen production，hydrogen fuel cells，hydrogen energy storage，and methane devices，is introduced on the source side，and the heat loss during operation is considered to construct an electricity-heat-gas-hydrogen efficient coupling model.Secondly，a waste heat power generation unit with an organic rankine cycle （ORC） is introduced on the source side to decouple the constraint of heat to electricity in cogeneration，and the demand response is supplemented on the load side to form a flexible and coordinated source-load response model.Finally，to address the impact of uncertainty in wind and photovoltaic power on system operation，a RIES low-carbon economic optimization model considering the conditional risk value theory is established，by comprehensively considering the costs of tiered carbon trading，equipment operation and maintenance，wind abandonment，and energy procurement.The proposed model is solved using the Gurobi solver.The research results show that the proposed model can effectively improve the level of new energy consumption，reduce the carbon emissions of systems，and improve energy utilization efficiency.