With the permeability increase of distributed power supply in active distribution network, the sensitivity is reduced and the coordination of protection is difficult due to the preset setting value of traditional over-current protection. Firstly, the characteristics of different control strategy types of distributed power supply are analyzed, and relationships among the output power, control mode, grid-connected voltage and fault current of distributed power supply are studied. Secondly, multi-source data fusion of active distribution network operation information is achieved according to the relationship between fault current and voltage, and an on-line adaptive setting strategy for current protection is then proposed. Aiming at the sensitivity reduction problem of the improved protection strategy due to the increase of grid-connected points and the further permeability of distributed power supply, the fault current matching calculation is carried out to realize the fault section searching by using the collected voltage and node admittance information. Finally, the effectiveness of the presented scheme is verified by PSCAD/EMTDC simulation combined with MATLAB programming.