In order to realize the adaptation of the protection strategy in distribution network, this paper divides the protection into fault identification circuit and operation decision circuit from the process relay protection. Furthermore, a two-level optimization method of distribution network protection strategy based on the integration of operation mode and fault information is proposed. First of all, relying on the operation mode tracking, the protection action setting of the fault identification circuit is set, and the fault information is generated; then, the fault information is integrated to realize the optimal setting of the protection operation decision circuit. This paper focuses on the optimization method of operation decision circuit based on fault information integration. Through fault topology analysis, protection operation coordination analysis and reclosing benefit analysis, this paper presents the adaptive optimization method of protection operation decision for distribution network relay protection in response to different fault scenarios, which effectively improves the flexibility of protection in distribution network.