Aiming at the differences in maximum wind speed and wind pressure distribution between typhoon wind field and conventional wind, this paper conducts wind tunnel test and wind-induced response analysis of 1 000 kV transmission tower in southeastern coastal areas. Based on the real data of typhoon, the wind profile index is fitted and the turbulence intensity is modified in landform category A for more fulfilling the real wind field. Through the high-frequency force balance test on 1 000 kV transmission tower, the average wind coefficients vary with different wind direction and the shape coefficients of whole tower, tower head and tower body is acquired. By using the harmonic wave superposition method to simulate turbulent wind velocity of all nodes in tower, equivalent static wind loads and wind vibration coefficients in varies operation conditions are obtained. Then, the sensitivity analysis of the structure damping, structure frequency, tower acceleration and maximum base load of the 1 000 kV tower in typhoon wind field is performed. Results indicate that acceleration response is sensitive to damping. Displacement response and acceleration response are sensitive to natural frequency.