In order to realize the adaptive optimization of the relay protection strategy of the distribution network, the protection is divided into the fault identification and exit decision-making process in terms of the fault handling process of the relay protection. On this basis, a two-level optimization method for relay protection strategy of the distribution network based on the fusion of operation mode and fault information is proposed. First of all, relying on the tracking of the running mode,the fixed values of the protection action in the fault identification process are set. Then, the fault information generated by the fault identification process is opened to the export decision-making process so as to realize the optimal setting of the export decision-making process. Finally, this paper focuses on the optimization method of the exit decision-making process integrating fault information. Through the fault topology, protection exit coordination and reclosing benefit analysis, the isolation action selection, exit fixed-value setting and reclosing strategy selection of protection exit decision-making for the distribution network relay protection in response to different fault scenarios are given to effectively improve the protection flexibility.